Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.
نویسندگان
چکیده
Immunosuppressed patients receiving oseltamivir for 2009 novel H1N1 influenza A infection may develop drug resistance, leading to treatment failure. Intravenous zanamivir was administered on a compassionate-use basis to a profoundly immunosuppressed pediatric patient with severe oseltamivir-resistant novel H1N1 pneumonia. The regimen was well tolerated and was associated with a decrease in viral burden.
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3. Halasa NB. Update on the 2009 pandemic infl uenza A H1N1 in children. Curr Opin Pediatr. 2010;22:83–7. DOI: 10.1097/ MOP.0b013e3283350317 4. Kidd IM, Down J, Nastouli E, Shulman R, Grant PR, Howell DC, et al. H1N1 pneumonitis treated with intravenous zanamivir. Lancet. 2009;374:1036. DOI: 10.1016/S0140-6736(09)61528-2 5. Gaur AH, Bagga B, Barman S, Hayden R, Lamptey A, Hoffman JM, et al. Int...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 50 11 شماره
صفحات -
تاریخ انتشار 2010